Correlation between urinary nicotine, cotinine and self-reported smoking status among educated young adults

Date Published:
2009
Citation-Indexed Journal:
Environmental Toxicology and Pharmacology. Volume 28, Issue 1, July 2009, Pages 92-96
Citation:
Correlation between urinary nicotine, cotinine and self-reported smoking status among educated young adults
Authors:
Man, C.N.,
Fathelrahman, A.I.,
Harn, G.L.,
Lajis, R.,
Samin, A.S.M.,
Omar, M.,
Awang, R.,
Bayanuddin, N.A.
Abstract:
The objective of this study was to correlate, differentiate and validate the self-reported smoking status of educated young adults with urinary biomarkers (i.e. nicotine and cotinine).

Freshmen students were recruited on voluntary basis. They filled-up self-administered questionnaire and their urine samples were collected for analysis. The urinary nicotine (UN) and cotinine (UC) were measured by gas chromatograph-mass spectrometry. Smokers, non-smokers and ex-smokers were found to be both significantly correlated and different in their UN and UC levels. UC level of 25 ng/ml was the optimal cut-off to differentiate smokers from non-smokers. Using this cut-off value, the prevalence of smoking among the students was found to be higher (15.4%) than the self-reported data (14.3%).

UC is useful in validating individual recent smoking history and the cut-off could serve as a marker for assessing the clinical impact of smoking and environmental tobacco smoke (ETS) exposure on human health.


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